This is what Amy had to say about the song in a interview with a Italian magazine in 2006:
“Lose Control” is less easy to explain. You know, when it comes to Evanescence I become really fussy and obsessive: I have to have control of everything, even the smallest details… I’m a “control freak”! I like to evaluate every single decision within the band. Sometimes I behave like this even in my private life and in this song I express, on the contrary, the desire to be less apprehensive and more “loose”, to let things go on their own, sometimes… to not always have the responsibility of everything.