Amy Lee describes the meaning of this song in the following quote:
The End Of the Dream is, just about life, and the end of the dream is death. You know it's about the journey and it's about, again, this recurring theme of not being afraid and living while you're alive because it doesn't last forever. I think that's something that comes out a lot in our music because it's something that I deeply feel.
It's funny though cause I'm always telling it to myself. It's not like you learn something and then just go 'Yeah, totally'... You have to make a constant effort to remind yourself of things that you believe in, you know. So I feel like, yeah that theme about not being afraid and life doesn't last forever... that comes out a lot. And yeah, that song is about that.
The song was chosen to be reworked on Synthesis, and Amy explained why:
I wanted to re-record The End of the Dream in a way that exposed the completely post traumatic healing of a survivor- taking the time to focus on the pain, and then look up and past it, gathering the strength to live on, better. Stronger. With a new understanding of the beauty of pain and the heartbreak of real life, not fly away from it, but carry it. Carry it all and feel grateful for it. Even proud.